Alcohol intolerance is a genetic condition that affects the body's ability to break down alcohol efficiently. It is caused by a mutation in the gene that codes for the enzyme aldehyde dehydrogenase (ALDH2), which is responsible for converting acetaldehyde, a toxic byproduct of alcohol metabolism, into acetic acid. This results in a buildup of acetaldehyde in the blood and tissues, leading to symptoms such as flushing of the skin, nausea, rapid heartbeat, and hypotension. While alcohol intolerance itself is not life-threatening, chronic alcohol consumption is associated with various diseases, including cancer, liver disease, cardiomyopathy, arrhythmias, high blood pressure, and pancreatitis.
In addition to alcohol intolerance, allergies to specific ingredients in beer, such as wheat, gluten, histamines, sulfites, and yeast, can also cause adverse reactions. These allergies are immune responses, whereas intolerances are digestive responses. Allergies to beer ingredients can result in symptoms such as gastrointestinal issues, rashes, itching, and in severe cases, anaphylaxis.
It is important to note that there is no safe level of alcohol consumption, and even low levels of alcohol intake are associated with increased risks of certain types of cancer, including oral, pharyngeal, laryngeal, esophageal, colorectal, liver, and breast cancer. Therefore, it is crucial to be aware of the potential health risks associated with alcohol consumption and to seek medical advice if any adverse reactions occur.
Characteristics | Values |
---|---|
Brain | Interferes with the brain's communication pathways, affecting mood, behaviour, clear thinking and coordination. |
Heart | Cardiomyopathy, arrhythmias, high blood pressure. |
Liver | Steatosis, cirrhosis, hepatocellular carcinoma, alcohol-associated hepatitis. |
Pancreas | Pancreatitis. |
Cancer | Mouth, throat, liver, colon, rectum, breast, oesophageal, pharynx, larynx. |
Immune System | Weakens the immune system, making the body more susceptible to diseases like pneumonia and tuberculosis. |
What You'll Learn
Auto-brewery syndrome
ABS is caused by an overgrowth of certain microorganisms in the gut, which break down carbohydrates into ethanol. The most common microorganisms involved include the yeast species Saccharomyces cerevisiae and Candida albicans, as well as various other yeasts and bacteria.
Risk factors for ABS include a high carbohydrate diet, prolonged antibiotic use, pre-existing conditions such as diabetes, and genetic variations that affect liver enzyme activity.
The effects of ABS can be harmful and wide-ranging. In addition to the immediate symptoms of intoxication, ABS can result in vitamin B6, zinc, and magnesium deficiencies. It can also lead to non-alcoholic fatty liver disease and its more severe form, non-alcoholic steatohepatitis (NASH). The condition can also have profound social and legal consequences, as individuals with ABS may be falsely accused of drunk driving or develop alcohol use disorder.
Diagnosis of ABS typically involves baseline tests, including blood tests to check metabolism and blood alcohol levels, as well as fecal testing for yeast growth. Doctors will also rule out other medical conditions with similar symptoms, such as neurological and psychiatric disorders. A definitive diagnosis can be made through a carbohydrate challenge test, which involves administering a dose of glucose and monitoring breath and blood alcohol levels at intervals.
Treatment for ABS involves a multidisciplinary approach, including medical professionals such as a primary care doctor, gastroenterologist, infectious disease specialist, nurse, and nutritionist. Lifestyle modifications, particularly dietary changes to reduce carbohydrate intake, are crucial. In some cases, antifungal or antibiotic medications may be prescribed, and probiotics may be recommended to restore gut bacteria balance.
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Cardiomyopathy
Alcohol-induced cardiomyopathy is a type of dilated cardiomyopathy, where the muscles of the heart stretch and enlarge, weakening the heart muscle and reducing its ability to pump blood effectively. This can disrupt the electrical system of the heart, causing arrhythmias, or irregular heart rhythms.
The condition can affect anyone who consumes too much alcohol, even those without alcohol use disorder. However, it is more likely to occur in people with alcohol use disorders or genetic mutations that cause them to process alcohol more slowly.
The symptoms of alcohol-induced cardiomyopathy include chest pain, fatigue, lightheadedness, heart palpitations, increased pressure and bulging of veins in the neck, trouble breathing, edema, decreased appetite, loss of muscle mass, and swelling or hardening of the liver.
The condition is caused by the toxic effects of alcohol, which strain the body's protective processes, especially in the liver, making them less effective over time. Consistent heavy drinking can lead to damage to multiple organ systems, including the heart.
Treatment for alcohol-induced cardiomyopathy involves helping the individual reduce their alcohol intake or stop drinking entirely, along with supportive care to prevent or reduce the impact of alcohol withdrawal symptoms. In many cases, abstaining from alcohol can lead to a full recovery. Medications such as beta-blockers and diuretics may also be prescribed to treat heart rhythm problems or other symptoms of heart failure.
The only way to cure alcohol-induced cardiomyopathy is with a heart transplant, but this is usually not an option due to the limited number of donor hearts available. Therefore, the best way to prevent and manage the condition is to reduce or abstain from alcohol consumption.
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Histamine intolerance
To diagnose histamine intolerance, a doctor may recommend keeping a food diary to identify any patterns between certain foods and symptoms. They may also suggest allergy testing, blood testing, histamine testing, or a colonoscopy to check histamine and DAO (diamine oxidase) levels and look for other conditions that could be causing the symptoms.
The main treatment for histamine intolerance is a change in diet, avoiding high-histamine foods and opting for fresh, whole foods. A low-histamine diet has been shown to reduce symptoms in people with histamine intolerance, with results visible in 3-4 weeks. It is also important to note that alcohol inhibits the production of DAO, an enzyme responsible for breaking down histamine, which can further contribute to histamine intolerance or overload. Therefore, it is generally recommended to avoid alcohol or consume it in very small amounts if you have histamine intolerance.
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Alcohol intolerance
Symptoms and Complications
The long-term effects of alcohol intolerance can be severe and may lead to major health problems, including an increased risk of cancers of the mouth, throat, oesophagus, stomach, and liver. Regular alcohol consumption can also increase the risk of heart disease and stroke.
It is important to distinguish between alcohol intolerance and an alcohol allergy. Alcohol intolerance is a digestive system disorder, while an alcohol allergy is an immune system response to ingredients in alcoholic beverages such as chemicals, grains, or preservatives. Allergic reactions can cause similar symptoms to alcohol intolerance, such as difficulty breathing, coughing, runny nose, or stomach upset. These symptoms can be triggered by a tiny amount of alcohol and are the result of the body creating antibodies against allergens.
Diagnosis and Treatment
If you experience any symptoms of alcohol intolerance or allergy, it is important to consult a doctor. They may conduct a physical exam and recommend tests such as skin tests or blood tests to determine the cause of your reaction.
The only way to avoid alcohol intolerance symptoms or allergic reactions is to abstain from alcohol or the specific beverage or ingredients that trigger the problem. For minor reactions, over-the-counter or prescription antihistamines may help reduce symptoms such as itching or hives. However, it is important to note that these medications do not reduce the susceptibility to the critical risks associated with alcohol intolerance.
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Allergies
Although alcohol intolerance is not a true allergy, it may be a reaction to something in an alcoholic beverage, such as chemicals, grains, or preservatives. Alcohol intolerance is caused by a genetic condition in which the body cannot break down alcohol efficiently. The most common signs and symptoms are a stuffy nose and skin flushing. Other symptoms include facial redness, red itchy skin bumps, worsening of pre-existing asthma, nausea, rapid heartbeat, hypotension, and a throbbing headache.
Histamine intolerance may also be a cause of an allergic reaction to beer. Histamine is a chemical created by the fermentation process and is present in beer. People with histamine intolerance have decreased or inhibited enzymes that break down histamine from food. As a result, they cannot prevent histamine from entering the bloodstream and causing symptoms such as headaches, hives, nasal congestion, and diarrhoea.
Sulfites, which are used as preservatives in beer and wine, can also cause allergic reactions. Sulfite allergy symptoms include asthma symptoms such as wheezing, coughing, and chest tightness, as well as allergic rhinitis symptoms such as nasal congestion, sneezing, and itching. In rare cases, a severe anaphylactic reaction may occur.
Gluten, which is present in wheat, rye, and barley, can also cause an allergic reaction. If you have a gluten allergy, sensitivity, or celiac disease, you must follow a gluten-free diet to prevent symptoms.
If you experience allergy symptoms after drinking beer, it is recommended to see a healthcare provider. They may refer you to an allergist or a gastroenterologist for further evaluation. The only way to prevent allergic reactions is to avoid the specific substance that causes the reaction.
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Frequently asked questions
An alcohol allergy is an immune system response — your immune system overreacts to an ingredient in alcohol. You may be allergic to one of the substances in alcohol (a chemical, grain, or preservative, such as sulfite). Alcohol intolerance is a genetic, metabolic disorder of the digestive system. Your body doesn't process alcohol the way it should.
Symptoms of an alcohol allergy include rashes, itchiness, swelling, and severe stomach cramps. Allergy symptoms are often more painful and uncomfortable than alcohol intolerance symptoms. In rare cases, if untreated, an alcohol allergy can be life-threatening.
Alcohol flushing syndrome is a major sign of alcohol intolerance. Your face, neck, and chest become warm and pink or red right after you drink alcohol. Other symptoms include nausea and vomiting, rapid heartbeat (tachycardia) or heart palpitations, hypotension (low blood pressure), throbbing headache, fatigue, and other hangover-like symptoms.